Endocrine Abstracts

Relevance: The main risk factors for developing diabetes type 2, such as obesity, overeating and a sedentary lifestyle are common to a variety of chronic non-infectious diseases.Purpose of the study: Investigate the source of epidemiological indicators, risk factors for type 2 diabetes based on cross-sectional study of the population of Almaty city and Almaty region of Kazakhstan.Methodology: The material for the research were popu...

Background: OPKO Biologics is a clinical-stage public company developing long-acting therapeutic proteins utilizing CTP technology. The technology involves fusion of the C-terminus peptide of human chorionic gonadotropin (hCG), a highly O-glycosylated peptide, to the target protein. CTP enabled the production of a long-acting human growth hormone (hGH) (MOD-4023) that supports a single-weekly injection in growth hormone-deficient patients. MOD-4023 is manufactured as a non-vis...

A 51-year-old man presented to an optometrist with a 3-week history of visual impairment following a minor headache. He was found to have reduced visual acuity 6/24 in both eyes and a dense bitemporal hemianopia and was referred urgently to Musgrove Park Emergency Department. MRI brain showed a cystic bleed from a pituitary macroadenoma, 30 mm in diameter, with compression of the optic chiasm. He had no clinical features of Cushing’s or other hormone excess or deficiency ...

Glucagon receptor KO mice are resistant to the clinical manifestations of diabetes induced by streptozotocin (STZ) and retain normal glycaemic control and glucose tolerance. In the present study the effects of chronic (18 days) once daily i.p. administration of two different glucagon receptor antagonists (GRA); desHis1Pro4Glu9-glucagon (GRA-1) and its related acylated peptide desHis1Pro4Glu9(Lys12PAL)...

Introduction: Human chorionic gonadotropin (hCG) is a glycoprotein hormone composed by two subunits, an alpha subunit common to all gonadotropins and a specific beta subunit. hCG is produced by trophoblast cells as differently glycosylated isoforms with a wide range of molecular weight, from 30 to 50 KDa (‘regular’ hCG is 37 KDa). hCG is used in the treatment of infertility. The aim of this study is to analyse and compare the composition of different commercial hCG.<...

The aim of the study was to evaluate frequency of cardiovascular events (myocardial infarction, stroke) among the individuals with metabolic syndrome (MS).Materials and methods: The study design was prospective. It was started in 2003 to assess the risk factors, clinical components, diagnostic criteria of MS and to determine correlation between MS and neuropsychiatric disorders. At the second stage in 2013 the individuals were repeatedly invited to evalu...

Introduction: Gigantomastia is a rare condition characterised by excessive benign breast tissue growth that is thought to be a result of elevated physiological levels of circulating hormones (e.g. pregnancy), or an increased sensitivity of the breast tissue to such hormones. Isolated reports describe some medical conditions as precipitants (e.g. systemic lupus erythematosus (SLE)) or drugs (e.g. cyclosporine). Many will proceed to surgical intervention to improve physical and/...

Introduction: Gynaecomastia (GM) is a major contributor to psychological morbidity in adolescent boys, yet there is a lack of evidence for effective treatment. It is known to develop due to the relatively higher diurnal oestradiol–testosterone ratio in early to mid puberty.Aims: We retrospectively looked to identify possible criteria for the selection of patients to predict optimal management of GM. We also examined the effect on the persistence of ...

Aims: To assess the prevalence, investigations and management of hyponatraemia in hospital inpatients (previously deemed inadequate) over a 2-week period (1–15 May 2013) and compare with data collected in 2011, following the introduction of updated clinical guidelines in our trust.Methods: Hospital notes and electronic records of all patients with a sodium level of <130 mmol/l were analysed.Results: 43/255 (17%) patients h...

A 58-year-old non-diabetic Caucasian man was admitted with a capillary glucose of 1.9 mmol/l following an episode of confusion and disorientation. During his admission he had frequent episodes of nocturnal and early morning hypoglycaemia with capillary glucose <3.0 mmol/l. After 21 h of supervised fasting he was symptomatic with plasma glucose 2.3 mmol/l, insulin >1000 mU/l and C-peptide 19.6 μg/l. Sulphonylurea screen was negative. Given the magnitude of serum in...